Hippocrates was the first to recognize that the disease was based on an alteration of moods and their relationship based on naturalistic philosophy of Empedocles had already described these humors: blood, lymph, black bile and yellow bile. Galen kept current theories of Hippocrates throughout medieval times turning them into dogmas.
Gradually they began to arise authors who saw the theories of Hippocrates as absolute truths. Vesalius based his study of disease in morphological aspects aside dogmatism tax at the time.
From the Renaissance began to make the first autopsy, began a new wave of authors who believe only what they could see, definitely away from the dogmatic ideas that until then prevailed.
Thus was born the organismic anatomy, morphology directly related to alterations and symptoms that accompany the disease.
The authors that appeared at the time and they discovered how valuable it was the autopsy for the study of medicine, such as Morgagni, were understanding that the observation and study of morphological alterations were the fundamental basis for understanding disease.
In the late eighteenth century, Bichat introduced the concept of tissue. I tried to find simple units that conform the organs, the world of pathology came that way in tissue era.
In the nineteenth century, thanks to the development of optical microscope, cell theory, which provided a level in the organization of living things was introduced. Robert Hooke was the first to speak of cork cells. Began in Germany relate to cells and alterations pathologies.
Claude Bernard also added that the physical and chemical characteristics of the cell and its changes are also related to the disease Lately pathology has experienced extraordinary development, thanks to advances in technology, medicine, biology, and so on. Also it can be said that the pathology is in continuous development.